Protein–Protein Communication Mediated by an Antibody‐Responsive DNA Nanodevice**

We report here the rational design and optimization of an antibody-responsive, DNA-based device that enables communication between pairs otherwise non-interacting proteins. The is designed to recognize bind a specific antibody and, in response, undergo conformational change leads release DNA strand, termed “translator,” regulates activity downstream target protein. As proof principle, we demonstrate antibody-induced control proteins thrombin Taq polymerase. resulting strategy versatile can be easily adapted protein–protein artificial regulatory networks.